A United Kingdom Value Set for the Weight-Specific Adolescent Instrument for Economic Evaluation

Objectives The Weight-Specific Adolescent Instrument for Economic Evaluation (WAItE) is a weight-specific patient-reported outcome measure for use in adolescence, consisting of 7 domains, each with 5 response levels. The objective of this study was to generate a UK value set for the WAItE, enabling the calculation of utility values. Methods An online discrete choice experiment (DCE) completed by an adult sample representative of the working population of the United Kingdom was used to estimate the preferences for the 5 levels of the 7 domains. DCE data were analyzed using multinomial and mixed logit models. The latent values were then anchored onto the 0-1 death-full health quality-adjusted life year scale using 2 different anchoring techniques, the time trade-off method and the DCE-visual analog scale method. Results A total of 1004 adults from the United Kingdom were included in the final estimation sample for the DCE. From the latent estimates, the majority of the levels of the dimensions followed the monotonic nature of the WAItE; however, some levels of the Tiredness-, Walking-, and Sports-related dimensions were not monotonic and combined to generate the final value set. The results from the time trade-off and DCE-visual analog scale anchoring methods were similar, with values for the PITS state (the worst health state possible from the WAItE) of 0.289 and 0.230. Conclusions This study has developed a value set for the WAItE based on the preferences of the UK population, enabling the use of the WAItE in cost-utility analyses of interventions targeting obesity in adolescents.